The Major League Baseball program is for players 'baseball age' 10-12 (10 yr old roster spots are not guaranteed), who have demonstrated a more advanced skill level through tryouts and a draft. The Major League Baseball program is the first introduction to competitive baseball, where a premium is placed on wins and losses, and equal playing time is not guaranteed.

Typically, roster spots are limited; not every League Age 10 player that registers and attends tryouts for the Major League Baseball will be drafted. Those 'baseball age' 10 year olds who tryout and are not drafted are placed in the pool of draft eligible players in the Minor League Baseball Division.

Players of league age 10-12 who participated in the Major League Baseball Division during the 2021 spring season and register for the 2022 Spring season are automatically returned to the same team unless a request is made prior to tryouts. All other players of league age 10-12 and who are not currently on a Major League Baseball team are required to tryout for the program. If a league age 10 player tries out and is drafted, he or she must play for that team or forfeit his or her registration and will not be allowed to participate in that season. The diamond used is 60-foot and the pitching distance is 46 feet.

Parents are strongly encouraged to become involved in Little League. After completing a Little League volunteer application and passing a required national background check, parents may become involved in practices and be eligible as coaches, managers, umpires, local league board members and other volunteer positions within the league.