| 03/26/2022 | White Sox | Padres | 2:00PM - 4:00PM | NASA Area Little League / Rudy T |
| 03/26/2022 | Astros | Cubs | 4:00PM - 6:00PM | NASA Area Little League / Rudy T |
| 03/29/2022 | Cubs | Padres | 5:45PM - 7:45PM | NASA Area Little League / Alves |
| 03/30/2022 | White Sox | Astros | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 04/01/2022 | Astros | Padres | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 04/02/2022 | Cubs | White Sox | 2:00PM - 4:00PM | NASA Area Little League / Rudy T |
| 04/05/2022 | Cubs | Astros | 5:45PM - 7:45PM | NASA Area Little League / Alves |
| 04/06/2022 | Padres | White Sox | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 04/09/2022 | Padres | Cubs | 12:00PM - 2:00PM | NASA Area Little League / Rudy T |
| 04/09/2022 | Astros | White Sox | 2:00PM - 4:00PM | NASA Area Little League / Rudy T |
| 04/12/2022 | Padres | Astros | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 04/13/2022 | White Sox | Cubs | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 04/19/2022 | Padres | Astros | 5:45PM - 7:45PM | NASA Area Little League / Alves |
| 04/22/2022 | White Sox | Padres | 5:45PM - 7:45PM | NASA Area Little League / Alves |
| 04/22/2022 | Astros | Cubs | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 04/26/2022 | Astros | Padres | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 04/30/2022 | Padres | White Sox | 10:00AM - 12:00PM | NASA Area Little League / Rudy T |
| 04/30/2022 | Cubs | Astros | 12:00PM - 2:00PM | NASA Area Little League / Rudy T |
| 05/02/2022 | White Sox | Astros | 5:45PM - 7:45PM | NASA Area Little League / Alves |
| 05/03/2022 | Cubs | Padres | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 05/05/2022 | Padres | Astros | 5:45PM - 7:45PM | NASA Area Little League / Alves |
| 05/05/2022 | White Sox | Cubs | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 05/07/2022 | Astros | Cubs | 10:00AM - 12:00PM | NASA Area Little League / Rudy T |
| 05/07/2022 | White Sox | Padres | 12:00PM - 2:00PM | NASA Area Little League / Rudy T |
| 05/11/2022 | Cubs | White Sox | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 05/12/2022 | Padres | Cubs | 5:45PM - 7:45PM | NASA Area Little League / Rudy T |
| 05/14/2022 | Astros | White Sox | 12:00PM - 2:00PM | NASA Area Little League / Rudy T |