| 06/06/2022 | Cheektowaga Bears | KNIGHTS 16U | 6:00PM - 8:00PM | Shoshone Park / Hofbrauhaus Diamond 5 | |
| 06/08/2022 | KNIGHTS 16U | MMB | 6:00PM - 8:00PM | Williamsville South High School / TBD 17U Knights | |
| 06/12/2022 | KNIGHTS 16U | Lockport Storm | 6:00PM - 8:00PM | TBD Away Games / TBD 17U Knights | |
| 06/13/2022 | Lancaster Depew | KNIGHTS 16U | 6:00PM - 8:00PM | McCarthy Park / McCarthy Diamond 1 90 | |
| 06/15/2022 | KNIGHTS 16U | Buffalo Elite | 6:00PM - 8:00PM | TBD Away Games / TBD 17U Knights | |
| 06/18/2022 | KNIGHTS 16U | Cayuga | 12:00PM - 2:00PM | TBD Away Games / TBD 16U Knights | |
| 06/19/2022 | Orchard Park | KNIGHTS 16U | 6:00PM - 8:00PM | Shoshone Park / Hofbrauhaus Diamond 5 | |
| 06/20/2022 | TBD | KNIGHTS 16U | 6:00PM - 8:00PM | McCarthy Park / McCarthy Diamond 1 90 | |
| 06/21/2022 | KNIGHTS 16U | Pioneer | 7:00PM - 9:00PM | Arcade Fields / Field 1 | |
| 06/23/2022 | KNIGHTS 16U | Clarence Storm | 6:00PM - 8:00PM | TBD Away Games / TBD 16U Knights | |
| 06/25/2022 | KNIGHTS 16U | Lakeshore | 6:00PM - 8:00PM | Lake Shore Little League / Diamond 2 | |
| 06/26/2022 | Amherst Panthers | KNIGHTS 16U | 2:00PM - 4:00PM | McCarthy Park / McCarthy Diamond 1 90 | |
| 06/28/2022 | Amherst Panthers | KNIGHTS 16U | 6:00PM - 8:00PM | McCarthy Park / McCarthy Diamond 1 90 | |
| 06/30/2022 | KNIGHTS 16U | Cheektowaga Vipers | 6:00PM - 8:00PM | Cheektowaga Beverly Hills Park / 90 foot | |
| 07/01/2022 | Midtown | KNIGHTS 16U | 6:00PM - 8:00PM | McCarthy Park / McCarthy Diamond 1 90 | Canceled |
| 07/03/2022 | Academy Stars | KNIGHTS 16U | 12:00PM - 2:00PM | Shoshone Park / Hofbrauhaus Diamond 5 | |
| 07/11/2022 | Cheektowaga Lightning | KNIGHTS 16U | 6:00PM - 8:00PM | McCarthy Park / McCarthy Diamond 1 90 | |
| 07/20/2022 | KNIGHTS 16U | Lancaster Depew | 6:00PM - 8:00PM | TBD Away Games / TBD 16U Knights | |
| 07/21/2022 | KNIGHTS 16U | Lakeview Lightning | 6:00PM - 8:00PM | Burke Road / Field 1 | |
| 07/24/2022 | Cambria Coyotes | KNIGHTS 16U | 6:00PM - 8:00PM | Shoshone Park / Hofbrauhaus Diamond 5 | |
| 07/26/2022 | KNIGHTS 16U | Buffalo Elite | 6:00PM - 8:00PM | TBD Away Games / TBD 16U Knights | |